病毒感染存在和不存在情况下急性淋巴细胞白血病患儿的中性粒细胞功能
Neutrophil function in children with acute lymphoblastic leukaemia in the presence and absence of viral infections.
作者信息
Reid M M, Craft A W, Low W T
出版信息
Arch Dis Child. 1979 Aug;54(8):619-22. doi: 10.1136/adc.54.8.619.
Neutrophil function was assessed regularly in 26 children with acute lymphoblastic leukaemia (ALL) in remission, both when they were well and during viral infections. Tests of candidacidal ability when these children were apparently free of infection showed a trend towards lower levels compared with controls. The most pronounced depression of candidacidal ability and chemotaxis was during viral infections, and these two functions of neutrophils were more likely to be abnormal then than when the children were free of infection. In children with ALL in remission, whose neutrophils may function abnormally even when they are well, the risk of acquiring bacterial or fungal infections may be made greater by virus infections.
对26名急性淋巴细胞白血病（ALL）缓解期儿童的中性粒细胞功能进行了定期评估，评估时间为他们健康时以及病毒感染期间。当这些儿童明显没有感染时，其杀念珠菌能力测试结果显示，与对照组相比有降低的趋势。杀念珠菌能力和趋化性最明显的降低发生在病毒感染期间，而且与儿童未感染时相比，中性粒细胞的这两种功能在此时更有可能出现异常。在ALL缓解期儿童中，即使他们健康时中性粒细胞功能也可能异常，病毒感染可能会增加他们获得细菌或真菌感染的风险。
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