Mercier P, Dallest R, Roux H
Rev Rhum Mal Osteoartic. 1980 Jul-Sep;47(7-9):465-70.
In a homogenous group of 31 cases of adult rheumatoid arthritis treated with gold salts and belonging to a caucasoid race in the South of France, HLA-DR groups were determined. The association with HLA-DR 4 was confirmed. DRw4 was present in 32.2 % of patients as against 12.9 % in 116 controls (p < 0.015). The relative risk of rheumatoid arthritis for DRw4 subjects is 3.3. This association is even more significant statistically in men, in spite of the small number studied (p < 0.005). The frequency of the DRw4 antigen is lower in the South than in the North of Europe (12.9 % as against 24 % respectively). The incidence of the disease and the problems of grouping for HLA-DRw4 and associated antigens are discussed.
在法国南部一组31例接受金盐治疗的成年类风湿性关节炎患者中，这些患者均为高加索人种，对其HLA - DR分组进行了测定。HLA - DR4的关联得到了证实。32.2%的患者存在DRw4，而116名对照者中这一比例为12.9%（p < 0.015）。DRw4受试者患类风湿性关节炎的相对风险为3.3。尽管研究的男性数量较少，但这种关联在男性中在统计学上更为显著（p < 0.005）。DRw4抗原在法国南部的频率低于北欧（分别为12.9%和24%）。文中讨论了该疾病的发病率以及HLA - DRw4和相关抗原的分组问题。
