58例类风湿关节炎患者的HLA - DR分型
HLA-DR typing in 58 cases of rheumatoid arthritis.
作者信息
Roux H, Bonnefoy-Cudraz M, Gaborit P, Mercier P, Dallest R
出版信息
Clin Rheumatol. 1982 Jun;1(2):112-6. doi: 10.1007/BF02275600.
The results of a previous study led us to believe that the association of HLA-DR4 and rheumatoid arthritis could be of particular interest in our region. In this work we typed 58 caucasoid patients in the Marseilles area by microlymphocytotoxicity assay in B-cells. HLA-DR4 was found to be at the same level as that observed by the authors in the 8th Workshop of histocompatibility (1980) (X2:32.36, P less than 0.001) and very high in the seropositive patients (61.5 per cent). No correlation with sex was observed. We again found a low frequency of HLA-DR4 (15.8 per cent) in our controls.
先前一项研究的结果使我们相信，HLA - DR4与类风湿性关节炎之间的关联在我们这个地区可能特别值得关注。在这项研究中，我们通过B细胞微量淋巴细胞毒性试验对马赛地区的58名白种人患者进行了分型。发现HLA - DR4的水平与组织相容性第八次研讨会（1980年）的作者所观察到的水平相同（X2：32.36，P小于0.001），并且在血清阳性患者中非常高（61.5%）。未观察到与性别的相关性。我们再次发现，在我们的对照组中HLA - DR4的频率较低（15.8%）。
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