头孢美唑在正常受试者及肾功能不全患者中的药代动力学。
Pharmacokinetics of cefmetazole in normal subjects and in patients with impaired renal function.
作者信息
Ohkawa M, Orito M, Sugata T, Shimamura M, Sawaki M, Nakashita E, Kuroda K, Sasahara K
出版信息
Antimicrob Agents Chemother. 1980 Sep;18(3):386-9. doi: 10.1128/AAC.18.3.386.
Abstract
The pharmacokinetics of cefmetazole, a new cephamycin antibiotic, were examined after a 1-h intravenous drip infusion of 1 g to 5 healthy volunteers with normal renal function and 16 patients with impaired renal function. Peak serum concentrations were obtained at the end of the infusion in all subjects, regardless of their renal function. Approximately 70% of the infused dose was excreted in the urine within 6 h in healthy volunteers. The pharmacokinetic parameters of cefmetazole were derived by analyzing elimination data, with a one-compartment open model. The mean serum half-life of cefmetazole in healthy volunteers was 0.81 h. A significant correlation between the elimination rate constant and the creatinine clearance was demonstrated.
摘要
对5名肾功能正常的健康志愿者和16名肾功能受损的患者静脉滴注1小时1克新头孢霉素抗生素头孢美唑后，研究了其药代动力学。无论肾功能如何，所有受试者在输注结束时均获得血清峰值浓度。在健康志愿者中，约70%的输注剂量在6小时内从尿液中排出。通过分析消除数据，采用单室开放模型得出头孢美唑的药代动力学参数。健康志愿者中头孢美唑的平均血清半衰期为0.81小时。消除速率常数与肌酐清除率之间存在显著相关性。
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