一种新型半合成7α-甲氧基头孢菌素，CS - 1170：7β-（（氰基甲基）硫代）乙酰胺基）-7α-甲氧基-3-（（1-甲基-1H-四氮唑-5-基）硫代）甲基）-3-头孢烯-4-羧酸。
A new semisynthetic 7alpha-methoxycephalosporin, CS-1170: 7beta-((cyanomethyl)thio)acetamido)-7alpha-methoxy-3-((1-methyl-1H-tetrazol-5-yl)thio)methyl)-3-cephem-4-carboxylic acid.
作者信息
Nakao H, Yanagisawa H, Shimizu B, Kaneko M, Nagano M
出版信息
J Antibiot (Tokyo). 1976 May;29(5):554-8. doi: 10.7164/antibiotics.29.554.
PMID:956044
Abstract
The synthesis and antimicrobial activity of a new semisynthetic 7alpha-methoxycephalosporin,7beta [[(cyanomethyl)thiol]acetamidol]-7alpha-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]-methyl]-3-cephem-4-carboxylic acid (CS-1170), are described. This compound shows interesting antibacterial activity when compared to cefoxitin and cephalothin.
摘要
描述了一种新型半合成7α-甲氧基头孢菌素7β[[(氰基甲基)硫醇]乙酰氨基]-7α-甲氧基-3-[[(1-甲基-1H-四氮唑-5-基)硫代]甲基]-3-头孢烯-4-羧酸（CS-1170）的合成及其抗菌活性。与头孢西丁和头孢噻吩相比，该化合物显示出有趣的抗菌活性。
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