Ash D V
Br J Cancer Suppl. 1980 Apr;4:17-20.
Patients with multiple measurable metastases can be used as their own perfectly matched controls to study the effect of different treatments on their metastases. Response to treatment may be assessed by sequential measurement of the regression and regrowth of the metastases and by assessment of the growth delay produced by each treatment. Three patients are described who have been studied in this way to investigate the addition of misonidazole to radiation. The results suggest that it is possible to obtain quantitative data that will discriminate between relatively small doses of radiation and provide interesting clinical information on tumour response. The problems of the method and its possible applications are discussed.
患有多处可测量转移灶的患者可作为自身完美匹配的对照，用于研究不同治疗方法对其转移灶的影响。可通过对转移灶的消退和再生长进行连续测量，以及评估每种治疗方法产生的生长延迟来评估治疗反应。本文描述了三名患者，他们以这种方式接受研究，以探究米索硝唑联合放疗的效果。结果表明，有可能获得定量数据，以区分相对小剂量的辐射，并提供有关肿瘤反应的有趣临床信息。本文还讨论了该方法的问题及其可能的应用。
