Dawen P J, Peckham M J, Steel G G
Br J Cancer Suppl. 1978 Jun;3:290-6.
In an attempt to investigate the radiosensitivity effect of the nitroimidazole misonidazole in man, sequential tumour volume measurements have been performed in 4 patients with metastatic malignant disease in order to compare the growth delay induced by radiation given before of 4 hours after the oral administration of the drug. One study was not completed, and there was no evidence of radiation sensitization in 2 patients. The results in the fourth patient were consistent with a small enhancement of radiation effect. Drug blood levels were followed on 9 occasions and tumour drug concentration measured in 1 patient.
为了研究硝基咪唑类药物米索硝唑对人体的放射增敏作用，对4例转移性恶性疾病患者进行了连续的肿瘤体积测量，以比较在口服该药物前4小时或后4小时给予放疗所导致的生长延迟情况。1项研究未完成，2例患者没有放射增敏的证据。第4例患者的结果与放射效应略有增强一致。9次监测了药物血药浓度，并在1例患者中测量了肿瘤药物浓度。
