Zschauer A, Hodel C
Arch Toxicol Suppl. 1980;4:466-70. doi: 10.1007/978-3-642-67729-8_110.
It is proposed to divide antispermatogenic compounds into four main groups on the basis of the morphological changes which they cause: a) Radiomimetic substances (e.g., Busulfan). These have a direct effect on spermatogonia and hence also on later sperm development. b) Substances inhibiting the meiotic and postmeiotic phases of spermatogenesis. These cause the seminal epithelium to disappear rapidly except for spermatogonia and Sertoli cells, which apparently remain intact (e.g., 20-438, an indenopyridine derivative). c) Substances acting hormonally (via pituitary). These severely damage Leydig cells, and there is a particularly pronounced degeneration of later stage spermatids. Sertoli cells are also affected. The tunica propria becomes thicker. The weights of the accessory sex glands decrease, and the pituitary weight increases. The peritubular tissue in the epididymis becomes thicker (e.g., 17 beta-estradiol). d) Vasoactive substances (e.g., cadmium chloride). These cause spot-like necrosis. Whole tubuli are destroyed (similar to infarction) whereas others can remain intact. Leydig cells also degenerate, and there is fibroblastic proliferation in the interstitium. The peritubular tissue in the epididymis becomes thicker and the secretion of clear cells is affected. Accessory glands lose weight.
根据抗生精化合物所引起的形态学变化，建议将其分为四大类：a) 类放射物质（如白消安）。这些物质对精原细胞有直接作用，因此也会影响后续精子的发育。b) 抑制精子发生减数分裂和减数分裂后阶段的物质。这些物质会使生精上皮迅速消失，仅精原细胞和支持细胞明显保持完整（如20 - 438，一种茚并吡啶衍生物）。c) 通过激素作用（经垂体）的物质。这些物质会严重损害睾丸间质细胞，后期精子细胞会出现特别明显的退化。支持细胞也会受到影响。固有膜变厚。附属性腺重量减轻，垂体重量增加。附睾的管周组织变厚（如17β - 雌二醇）。d) 血管活性物质（如氯化镉）。这些物质会导致点状坏死。整个小管被破坏（类似于梗死），而其他小管可能保持完整。睾丸间质细胞也会退化，间质中会有成纤维细胞增殖。附睾的管周组织变厚，透明细胞的分泌受到影响。附属腺体重减轻。
