Kumar N B, Naylor B
J Clin Pathol. 1980 Dec;33(12):1153-9. doi: 10.1136/jcp.33.12.1153.
Over a period of 22 years, 4844 pleural and peritoneal fluids from 3279 patients were examined cytologically. Megakaryocytes were found in the fluids from five patients. The clinical diagnoses in the five patients were agnogenic myeloid metaplasia, chronic myeloid leukaemia, and lymphocytic lymphoma. All of these patients had persistent serous effusions. Megakaryocytes in serous fluids occurred in three forms: (1) a large type with abundant cytoplasm and multilobed nuclei, (2) a smaller type with a high nucleocytoplasmic ratio and unlobed nuclei, and (3) anucleate cytoplasmic masses. Foci of agnogenic myeloid metaplasia found on the serous surfaces at necropsy of two patients contained megakaryocytes similar to those in the corresponding effusions. The clinical course of our patients confirmed that the presence of megakaryocytes in serous fluids signifies an advanced haematopoietic malignancy.
在22年的时间里，对3279例患者的4844份胸水和腹水进行了细胞学检查。在5例患者的体液中发现了巨核细胞。这5例患者的临床诊断为特发性骨髓化生、慢性粒细胞白血病和淋巴细胞淋巴瘤。所有这些患者都有持续性浆液性积液。浆液性体液中的巨核细胞有三种形式：(1) 一种大细胞类型，胞质丰富，核分叶；(2) 一种较小的细胞类型，核质比高，核未分叶；(3) 无核细胞质团块。在2例患者尸检时发现的浆液性表面的特发性骨髓化生灶含有与相应积液中相似的巨核细胞。我们患者的临床病程证实，浆液性体液中巨核细胞的存在表明存在晚期造血系统恶性肿瘤。
