钠离子对培养的肾上皮细胞生长的诱导作用。
Induction of growth in kidney epithelial cells in culture by Na+.
作者信息
Toback F G
出版信息
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6654-6. doi: 10.1073/pnas.77.11.6654.
Abstract
The role of Na+ in the regulation of cell growth was examined in quiescent, high-density cultures of kidney epithelial cells of the BSC-1 line. The addition of NaCl to the medium increased the number of cells initiating DNA synthesis in a concentration-dependent manner after serum stimulation. In the presence of added NaCl, cells in confluent cultures grew to high density at an increased rate, whereas growth in sparse cultures was retarded. These results suggest that, in the presence of serum, Na+ can act as a mediator of the events that initiate cell proliferation.
摘要
在BSC - 1系肾上皮细胞的静止、高密度培养物中研究了Na⁺在细胞生长调节中的作用。血清刺激后，向培养基中添加NaCl以浓度依赖的方式增加了启动DNA合成的细胞数量。在添加了NaCl的情况下，汇合培养物中的细胞以更快的速度生长至高密度，而稀疏培养物中的生长则受到抑制。这些结果表明，在有血清存在的情况下，Na⁺可以作为启动细胞增殖事件的介质。
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