Larson H E
Scand J Infect Dis Suppl. 1980(Suppl 22):7-10.
Findings from several countries now closely associate Clostridium difficile and its toxin with PMC. In fact, testing for the toxin by means of tissue culture assay is being used more and more to define the proportion of patients with clinically significant antibiotic associated colitis. Reproduction of a similar entity in hamsters appears to fulfil the Koch-Henle postulates, establishing C. difficile as the cause of the syndrome. Antibiotic treatment creates susceptibility to infection rather than being directly responsible for the lesions. The manner in which this occurs is not clear. Animal experiments show that C. difficile is present in some environments and that it may spread through the air and be ingested to cause infection.
现在，来自多个国家的研究结果表明，艰难梭菌及其毒素与伪膜性结肠炎密切相关。事实上，越来越多地通过组织培养检测法来检测毒素，以确定具有临床意义的抗生素相关性结肠炎患者的比例。在仓鼠身上复制出类似的病症似乎满足了科赫-亨利法则，确立了艰难梭菌为该综合征的病因。抗生素治疗会使人易受感染，而非直接导致病变。其发生方式尚不清楚。动物实验表明，艰难梭菌存在于某些环境中，可能通过空气传播并被摄入从而引发感染。
