Mitchell K F, Fuhrer J P, Steplewski Z, Koprowski H
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7287-91. doi: 10.1073/pnas.77.12.7287.
This report describes the structures of three distinct human melanoma surface antigens detected by monoclonal anti-melanoma antibodies. One antigen, expressed on all melanoma cells and on certain astrocytoma cells but not on any other kind of normal or tumor cell tested, has been shown to consist of our associated polypeptide chains. A second antigen expressed on many but not all melanomas has been identified as the antigenic product of the HLA-D locus, the DR antigen. A third protein antigen is not found on any normal cell tested but occurs on some, but not all, tumors of various origins.
本报告描述了通过单克隆抗黑色素瘤抗体检测到的三种不同的人类黑色素瘤表面抗原的结构。一种抗原在所有黑色素瘤细胞和某些星形细胞瘤细胞上表达，但在任何其他测试的正常或肿瘤细胞上均未表达，已证明它由四条相关的多肽链组成。在许多但并非所有黑色素瘤上表达的第二种抗原已被鉴定为HLA - D位点的抗原产物，即DR抗原。第三种蛋白质抗原在任何测试的正常细胞上均未发现，但在一些（并非全部）各种起源的肿瘤上出现。
