Brown W A, Qualls C B
Psychiatry Res. 1981 Apr;4(2):115-28. doi: 10.1016/0165-1781(81)90015-9.
The data from a series of studies in different patient samples are consistent in showing that resistance to dexamethasone suppression is selectively associated with primary major depressive disorder. In addition, nonsuppressors appear to have more depressive episodes, show greater improvement during hospitalization, tend to be older than suppressors, and may have a specific disturbance in cognitive function. Preliminary data suggest that nonsuppressors and suppressors respond preferentially to different antidepressants. These data raise the possibility that pituitary-adrenal disinhibition, as assessed by the dexamethasone suppression test, is associated with a depressive subtype having a distinctive pathophysiology, clinical course, and treatment response.
一系列针对不同患者样本的研究数据一致表明，对地塞米松抑制的抵抗与原发性重度抑郁症存在选择性关联。此外，非抑制者似乎有更多抑郁发作，在住院期间改善更明显，往往比抑制者年龄更大，且可能存在特定的认知功能障碍。初步数据表明，非抑制者和抑制者对不同的抗抑郁药有优先反应。这些数据增加了一种可能性，即通过地塞米松抑制试验评估的垂体 - 肾上腺去抑制与一种具有独特病理生理学、临床病程和治疗反应的抑郁亚型相关。
