关于自私DNA数量的一些计算。
Some calculations on the amount of selfish DNA.
作者信息
Ohta T, Kimura M
出版信息
Proc Natl Acad Sci U S A. 1981 Feb;78(2):1129-32. doi: 10.1073/pnas.78.2.1129.
A population genetical theory is developed to treat the amount of selfish DNA in a genome. We assume that the selfish DNA consists of replicating units and that it evolves by multiplication within a genome, exchange between genomes, and random genetic drift at reproduction. Special reference is made to the mean and variance of the number of replicating units per genome in the population. Under the assumption of no systematic evolutionary pressure, the number of units changes randomly with time, and its variance increases by replication process. Although under certain circumstances the variance increases also by exchange process, under ordinary circumstances this process tends to decrease the variance. Random genetic drift also reduces the variance. The relationship between the mean and variance at equilibrium of the number of replicating units per genome in the population was derived. The results obtained will be useful in understanding various observations on repeated DNA which presumably does not contain genetic information and which is likely to be selectively neutral.
一种群体遗传学理论被发展出来以处理基因组中自私DNA的数量。我们假设自私DNA由复制单元组成，并且它通过在基因组内的增殖、基因组间的交换以及繁殖时的随机遗传漂变而进化。特别提及了群体中每个基因组复制单元数量的均值和方差。在没有系统进化压力的假设下，单元数量随时间随机变化，并且其方差通过复制过程增加。尽管在某些情况下方差也会通过交换过程增加，但在通常情况下这个过程倾向于减小方差。随机遗传漂变也会减小方差。推导了群体中每个基因组复制单元数量在平衡时均值和方差之间的关系。所得到的结果将有助于理解关于重复DNA的各种观察结果，这些重复DNA大概不包含遗传信息并且可能是选择性中性的。
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