癌症发生的基因扩增模型。
Gene-amplification model of carcinogenesis.
作者信息
Pall M L
出版信息
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2465-8. doi: 10.1073/pnas.78.4.2465.
Abstract
A two-stage model of carcinogenesis is proposed based on recent evidence for the occurrence of proto-oncogenes in the vertebrate genome, evidence for gene amplification during carcinogenesis, and studies of the action of tumor promoters. The model is baed on the view that an increase in the level of gene product from such proto-oncogenes is sufficient to induce neoplastic transformation. It proposes that the initial step in carcinogenesis (initiation) is a mutation producing a tandem duplication of a proto-oncogene. Gene amplification can then occur by successive unequal sister chromatid crossing-over events in several cell cycles until sufficient gene product is produced to transform the cell.
摘要
基于脊椎动物基因组中原癌基因存在的最新证据、致癌过程中基因扩增的证据以及肿瘤启动子作用的研究，提出了一个两阶段致癌模型。该模型基于这样一种观点，即来自此类原癌基因的基因产物水平的增加足以诱导肿瘤转化。它提出致癌作用的初始步骤（启动）是产生原癌基因串联重复的突变。然后，在几个细胞周期中通过连续的不等姐妹染色单体交叉事件可发生基因扩增，直到产生足够的基因产物来转化细胞。
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本文引用的文献
1
MINUTE CHROMATIN BODIES IN MALIGNANT TUMOURS OF CHILDHOOD.儿童恶性肿瘤中的微小染色质体
Lancet. 1965 Jul 10;1(7402):55-8. doi: 10.1016/s0140-6736(65)90131-5.
2
Characterization of cell lines from four undifferentiated human malignancies.
Cancer. 1980 May 1;45(9):2311-23. doi: 10.1002/1097-0142(19800501)45:9<2311::aid-cncr2820450914>3.0.co;2-w.
3
Transforming genes of retroviruses.逆转录病毒的转化基因。
Cold Spring Harb Symp Quant Biol. 1980;44 Pt 1,:13-29. doi: 10.1101/sqb.1980.044.01.005.
4
Endogenous virogenes and oncogenes in rat-cell transformation: a new model system.大鼠细胞转化中的内源性病毒基因和癌基因：一种新的模型系统。
Cold Spring Harb Symp Quant Biol. 1980;44 Pt 2,:779-86. doi: 10.1101/sqb.1980.044.01.084.
5
Viral oncogenes.
Cold Spring Harb Symp Quant Biol. 1980;44 Pt 1,:1-7.
6
Origin and function of avian retrovirus transforming genes.禽逆转录病毒转化基因的起源与功能。
Cold Spring Harb Symp Quant Biol. 1980;44 Pt 2,:919-30. doi: 10.1101/sqb.1980.044.01.099.
7
Structure and expression of the Abelson murine leukemia virus genome and its relationship to a normal cell gene.阿贝尔逊鼠白血病病毒基因组的结构与表达及其与正常细胞基因的关系。
Cold Spring Harb Symp Quant Biol. 1980;44 Pt 2,:849-54. doi: 10.1101/sqb.1980.044.01.090.
8
Comparative analysis of cellular and viral sequences related to sarcomagenic cell transformation.
Cold Spring Harb Symp Quant Biol. 1980;44 Pt 2,:755-64. doi: 10.1101/sqb.1980.044.01.081.
9
Three new types of viral oncogenes in defective avian leukemia viruses. I. Specific nucleotide sequences of cellular origin correlate with specific transformation.缺陷型禽白血病病毒中的三种新型病毒癌基因。I. 细胞来源的特定核苷酸序列与特定转化相关。
Cold Spring Harb Symp Quant Biol. 1980;44 Pt 2,:1215-23. doi: 10.1101/sqb.1980.044.01.132.
10
Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus.与莫洛尼肉瘤病毒src序列同源的正常小鼠细胞DNA序列（sarc）的特性。
Science. 1980 Mar 14;207(4436):1222-4. doi: 10.1126/science.6243788.
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