Hall C N, Darkin D, Viney N, Cook A, Kirkham J S, Northfield T C
Norman Tanner Gastroenterology Unit, St James' Hospital, Balham, London, UK.
IARC Sci Publ. 1987(84):527-30.
Patients who had undergone a Billroth II gastrectomy (PG) or had pernicious anaemia (PA) and healthy matched control subjects (MC) participated in 24-h studies in which bacteria, nitrite and N-nitroso compounds (NOC) were measured in gastric juice and N-nitrosoproline (NPRO) in urine. Consistent with the nitrosamine hypothesis, intragastric levels of bacteria and nitrite were positively related to intragastric pH, but, contrary to the hypothesis, NOC in gastric juice and NPRO in urine were negatively related to intragastric pH.
接受过毕Ⅱ式胃切除术（PG）或患有恶性贫血（PA）的患者以及健康匹配对照受试者（MC）参与了一项为期24小时的研究，该研究测量了胃液中的细菌、亚硝酸盐和N-亚硝基化合物（NOC）以及尿液中的N-亚硝基脯氨酸（NPRO）。与亚硝胺假说一致，胃内细菌和亚硝酸盐水平与胃内pH呈正相关，但与该假说相反，胃液中的NOC和尿液中的NPRO与胃内pH呈负相关。
