Petkova R, Vasilev N, Boiadzhiev P
Eksp Med Morfol. 1981;20(2):96-100.
The authors examined the changes in the morphology of leucaemic lymphoblasts, obtained from cerebrospinal fluid and changes in the cellular content of meningograms after treatment of Meningosis leucaemica with amethopterin. On the basis of the degree of cytoplasmic and nuclear damage paraleucoblasts were divided into three types: Type I - undamaged paraleucoblasts Type 2 - paraleucoplasts with a slight degree of damage, mainly cytoplasmic Type 3 - parleucoblasts with grave degree of damage, mainly nuclear. In the course of the therapy there was a reduction of the number of nondamaged leucaemic cells, which was accompanied with an increase in the number of damaged leucaemic lymphoblasts, lymphoids, lymphocytes and neutrophils. The damage of paraleucoblasts as well as the difference in the ratio of single cellular elements showed dependence on the number of intrathecal applications of the cytostatic. The described cytologic criteria could be used for prescription, control and checking the effect of intrathecal treatment of Meningosis leucaemica with amethopterin.
作者研究了从脑脊液中获取的白血病淋巴母细胞形态的变化，以及用氨甲蝶呤治疗白血病性脑膜炎后脑膜造影细胞成分的变化。根据细胞质和细胞核的损伤程度，副原始白细胞分为三种类型：I型——未受损的副原始白细胞；2型——轻度受损的副原始白细胞，主要是细胞质受损；3型——严重受损的副原始白细胞，主要是细胞核受损。在治疗过程中，未受损白血病细胞数量减少，同时受损白血病淋巴母细胞、类淋巴细胞、淋巴细胞和中性粒细胞数量增加。副原始白细胞的损伤以及单个细胞成分比例的差异显示出依赖于鞘内应用细胞抑制剂的次数。所描述的细胞学标准可用于指导、控制和检查用氨甲蝶呤鞘内治疗白血病性脑膜炎的效果。
