Péter A
Haematologia (Budap). 1976;10(1):95-8.
In the cerebrospinal fluid of 45 patients, 240 cytological examinations has been performed. Sixteen patients were investigated serially in the course of intrathecal methotrexate treatment. The different mechanisms of nuclear fragmentation, various types of cytoplasmic vacuoles and the features of the reticulo-histiocytic reactions due to methotrexate has been analyzed. The morphological changes caused by methotrexate are attributed to depend on the cell type and on its response to therapy.
对45例患者的脑脊液进行了240次细胞学检查。16例患者在鞘内注射甲氨蝶呤治疗过程中接受了系列检查。分析了甲氨蝶呤所致核碎裂的不同机制、各种类型的细胞质空泡以及网状组织细胞反应的特征。甲氨蝶呤引起的形态学变化被认为取决于细胞类型及其对治疗的反应。
