Yam L T, Janckila A J, Li C Y, Lam W K
Invest Urol. 1981 Jul;19(1):34-8.
The occurrence of natural substances with antigenic properties similar to those of the prostatic acid phosphatase was examined in one patient with neutrophilic leukemia and increased activity of serum acid phosphatase. The fraction responsible for the increased serum enzyme activity was tartrate sensitive and was identified as isoenzyme 2 by polyacrylamide gel electrophoresis. This isoenzyme originated from the leukocytes but had similar electromobility to that of the prostatic acid phosphatase isoenzyme 2. Immunohistochemical and counterimmunoelectrophoretic studies indicated that this leukocytic isoenzyme was present in the neutrophils and shared antigenic properties with the prostatic isoenzyme 2. Leukocytes from one patient with acute granulocytic leukemia, two patients with polycythemia vera with neutrophilia, and five normal subjects also contained this prostatic acid phosphatase like isoenzyme. Elevated serum "prostatic" acid phosphatase activity, therefore, may be found not only in prostatic cancer but also in granulocytic leukemia and perhaps other diseases.
在一名中性粒细胞白血病患者中，检测了具有与前列腺酸性磷酸酶相似抗原特性的天然物质的存在情况，该患者血清酸性磷酸酶活性升高。导致血清酶活性增加的部分对酒石酸盐敏感，通过聚丙烯酰胺凝胶电泳鉴定为同工酶2。这种同工酶起源于白细胞，但电泳迁移率与前列腺酸性磷酸酶同工酶2相似。免疫组织化学和对流免疫电泳研究表明，这种白细胞同工酶存在于中性粒细胞中，并与前列腺同工酶2具有共同的抗原特性。一名急性粒细胞白血病患者、两名真性红细胞增多症伴中性粒细胞增多患者以及五名正常受试者的白细胞中也含有这种类似前列腺酸性磷酸酶的同工酶。因此，血清“前列腺”酸性磷酸酶活性升高不仅可能见于前列腺癌，还可能见于粒细胞白血病以及其他疾病。
