急性髓系白血病中的8号与21号染色体易位

8/21 translocation in acute myeloid leukaemia.

作者信息

Tricot G, Broeckaert-van Orshoven A, Casteels-van Daele M, van den Berghe H

出版信息

Scand J Haematol. 1981 Feb;26(2):168-76. doi: 10.1111/j.1600-0609.1981.tb01642.x.

DOI:10.1111/j.1600-0609.1981.tb01642.x

Abstract

8;21 translocation was found in 10 AML patients. These patients exhibited a distinct clinical and haematological picture, characterized by M2 bone marrow, with rather good maturation, a high count of mature granulocytes, splenomegaly, and the absence of DIC. Complete remission as easily obtained. It was reported that the median survival is better than for other AML patients with abnormal karyotypes, but this could not be substantiated in our small series. The loss of a sex chromosome was found to be frequent and of poor prognostic significance.

摘要

在10例急性髓系白血病（AML）患者中发现了8;21易位。这些患者呈现出独特的临床和血液学表现，其特征为M2型骨髓，成熟度较好，成熟粒细胞计数较高，脾肿大，且无弥散性血管内凝血（DIC）。很容易获得完全缓解。据报道，这些患者的中位生存期优于其他核型异常的AML患者，但在我们的小样本系列中无法证实这一点。发现性染色体丢失很常见，且预后意义不佳。