Mertelsmann R, Gillis S, Steinmann G, Ralph P, Stiehm M, Koziner B, Moore M A
Blut. 1981 Aug;43(2):99-103. doi: 10.1007/BF00320468.
Mononuclear blood cells from patients with different types of leukemia, and from controls as well as cells from established lymphoblastic cell lines were analyzed with respect to terminal transferase (TdT) activity and T-cell growth factor (TCGF; Interleukin 2, IL-2), to determine the significance of TCGF production and response as functional markers for human leukemias. The data obtained so far suggest that the aberrant proliferation and lack of maturation observed in these leukemias may be associated with or be the result of a break-down in cellular-mediated control of proliferation.
对来自不同类型白血病患者、对照者的单核血细胞以及已建立的淋巴细胞系的细胞进行了末端转移酶（TdT）活性和T细胞生长因子（TCGF；白细胞介素2，IL-2）分析，以确定TCGF产生和反应作为人类白血病功能标志物的意义。目前获得的数据表明，在这些白血病中观察到的异常增殖和成熟障碍可能与细胞介导的增殖控制破坏有关，或者是其结果。
