Sadamori N, Ikeda S, Muta T, Ichimaru M, Matsunaga M
Cancer Genet Cytogenet. 1981 Jun;3(4):353-7. doi: 10.1016/0165-4608(81)90045-5.
In a 22-year-old female with Philadelphia chromosome (Ph1)-positive chronic myelogenous leukemia (CML) a tumor consisting of megaloblastic proerythroblasts appeared in the right ilio-femoral region 2 years and 8 months after the diagnosis of the disease and was treated effectively with irradiation. She developed erythroblastic transformation 3 months after the tumor appeared. Cytogenetic study of the bone marrow cells in the acute phase revealed marked chromosomal rearrangements such as ring, dicentric, or tricentric chromosomes.
在一名22岁费城染色体（Ph1）阳性慢性粒细胞白血病（CML）女性患者中，在疾病诊断后2年8个月，右髂股区域出现了一个由巨幼样早幼红细胞组成的肿瘤，经放射治疗有效。肿瘤出现3个月后，她发生了红系转化。急性期骨髓细胞的细胞遗传学研究显示出明显的染色体重排，如环状、双着丝粒或三着丝粒染色体。
