吖啶染料和其他DNA嵌入剂可诱导发光细菌及其暗变体的发光系统。
Acridine dyes and other DNA-intercalating agents induce the luminescence system of luminous bacteria and their dark variants.
作者信息
Ulitzur S, Weiser I
出版信息
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3338-42. doi: 10.1073/pnas.78.6.3338.
Abstract
Acridine dyes and other DNA-intercalating agents such as ethidium bromide, theophylline, and caffeine induce luminescence in dark variants (K variants) different luminous species of bacteria, as well as in their wild-type luminous cells, prior to induction. The increase in luminescence appears 10-20 min after addition of these agents and is inhibited by chloramphenicol or rifampicin. Addition of these agents affects the synthesis of both luciferase and aldehyde-synthesizing enzymes. It is hypothesized that these agents, through their intercalation into DNA, cause configurational changes resulting in derepressed transcription of the luminescence operon.
摘要
吖啶染料及其他DNA嵌入剂，如溴化乙锭、茶碱和咖啡因，在诱导之前可使不同发光种类细菌的暗变体（K变体）以及它们的野生型发光细胞发光。添加这些试剂后10 - 20分钟会出现发光增强，且会被氯霉素或利福平抑制。添加这些试剂会影响荧光素酶和醛合成酶的合成。据推测，这些试剂通过嵌入DNA，引起构象变化，导致发光操纵子的转录去抑制。
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