Kyriakos M, Murphy W A
Skeletal Radiol. 1981;6(3):179-86. doi: 10.1007/BF00347184.
The case of a 15-year-old girl with juxtaposition of a femoral metaphyseal fibrous defect (fibrous cortical defect) and an osteosarcoma is reported. Despite the relatively common occurrence of metaphyseal fibrous defects, their reported association with other bone tumors is exceedingly rare. Only two previous acceptable examples of this association were found. Reports of malignant transformation of metaphyseal fibrous defect were reviewed and rejected because they lacked convincing radiologic or histopathologic evidence of a pre-existent benign fibrous lesion. The finding of a malignant bone tumor in association with a metaphyseal fibrous defect appears to be a chance occurrence.
报告了一名15岁女孩股骨干骺端纤维性缺损（纤维性骨皮质缺损）与骨肉瘤并存的病例。尽管干骺端纤维性缺损相对常见，但其与其他骨肿瘤的关联报道极为罕见。仅发现此前有两个可接受的这种关联的例子。对干骺端纤维性缺损恶变的报告进行了审查并予以否定，因为它们缺乏令人信服的影像学或组织病理学证据证明存在先前的良性纤维性病变。发现恶性骨肿瘤与干骺端纤维性缺损并存似乎是一种偶然现象。
