Green W R, Quigley H A, De la Cruz Z, Cohen B
Trans Ophthalmol Soc U K (1962). 1980 Apr;100(Pt 1):162-70.
The clinical, histopathological, and ultrastructural features of a case of parafoveal telangiectasis are reported. No telangiectasis of retinal vessels was found. Instead, there was thickening of the wall of the retinal capillaries and narrowing of the calibre of the lumen. Thickening was due to marked proliferation of basement membrane in a multilayered configuration, Cellular debris from degenerated endothelial cells and pericytes, and multimembranous lamellar lipid material were entrapped between layers of basement membrane. Extensive degeneration of pericytes was observed, and occasional areas showed degenerated endothelial cells. These changes were not restricted to the clinical-affected parafoveal area but were also seen to a lesser degree throughout the retina. The changes are interpreted as being due to primary endothelial cell degeneration and regeneration, with successive waves of basement membrane production and secondary degeneration of pericytes.
报告了一例黄斑旁毛细血管扩张症的临床、组织病理学和超微结构特征。未发现视网膜血管的毛细血管扩张。相反，视网膜毛细血管壁增厚，管腔口径变窄。增厚是由于基底膜呈多层结构明显增生，退化的内皮细胞和周细胞的细胞碎片以及多膜层状脂质物质被困在基底膜层之间。观察到周细胞广泛退化，偶尔可见内皮细胞退化区域。这些变化不仅局限于临床受累的黄斑旁区域，在整个视网膜中也有较轻程度的出现。这些变化被解释为原发性内皮细胞退化和再生，伴随着基底膜的连续生成以及周细胞的继发性退化。
