Fraser J R, Cunningham A L, Clarris B J, Aaskov J G, Leach R
Aust N Z J Med. 1981 Apr;11(2):168-73. doi: 10.1111/j.1445-5994.1981.tb04226.x.
Examination of synovial fluid in eight patients with epidemic polyarthritis following Ross River virus infection showed cell counts ranging from 1,500 to 13,800 per mm3. Stained smears were notable for a paucity of neutrophils and high proportions of monocytes and vacuolated macrophages, which were further characterised by light and electron microscopy. Ross River virus antigen was detected by specific immunofluorescence in monocytes and macrophages of four cases early in the course of the illness, but intact virus was not identified by electron microscopy or cell culture. No cell-associated C3 component of complement or immunoglobulin of IgM or IgG class was detected in any cell-type. These findings indicate that cell counts and simple smears may be useful in the early diagnosis of suspected epidemic polyarthritis, and provide further information pertinent to the pathogenesis of this disease.
对8例罗斯河病毒感染后流行性多关节炎患者的滑液进行检查，结果显示细胞计数范围为每立方毫米1500至13800个。染色涂片的特点是中性粒细胞数量少，单核细胞和空泡化巨噬细胞比例高，通过光学显微镜和电子显微镜对其进行了进一步表征。在病程早期，4例患者的单核细胞和巨噬细胞中通过特异性免疫荧光检测到罗斯河病毒抗原，但通过电子显微镜或细胞培养未鉴定出完整病毒。在任何细胞类型中均未检测到与细胞相关的补体C3成分或IgM或IgG类免疫球蛋白。这些发现表明，细胞计数和简单涂片可能有助于疑似流行性多关节炎的早期诊断，并为该疾病的发病机制提供了更多相关信息。
