Aaskov J G, Fraser J R, Dalglish D A
Aust J Exp Biol Med Sci. 1981 Oct;59(Pt 5):599-608. doi: 10.1038/icb.1981.52.
T-lymphocytes from epidemic polyarthritis patients exhibited a virus specific proliferative response when exposed to Ross River virus in vitro. The magnitude of this response was greater than that of lymphocytes from asymptomatic seropositive donors. The natural killer cell activity of peripheral blood mononuclear leucocytes from these patients was depressed early in disease but returned to normal levels as the severity of the symptoms decreased. Although no in vivo role can yet be assigned to natural killer cells in epidemic polyarthritis, changes in their activity appeared to be more closely associated with the presence or absence of disease symptoms than were levels of anti-viral antibody or the ability or T-lymphocytes from peripheral blood to proliferate on re-exposure to Ross River virus.
流行性多关节炎患者的T淋巴细胞在体外接触罗斯河病毒时表现出病毒特异性增殖反应。这种反应的强度大于无症状血清阳性供体的淋巴细胞。这些患者外周血单个核白细胞的自然杀伤细胞活性在疾病早期降低，但随着症状严重程度的减轻恢复到正常水平。尽管在流行性多关节炎中尚未确定自然杀伤细胞在体内的作用，但与抗病毒抗体水平或外周血T淋巴细胞再次接触罗斯河病毒时增殖的能力相比，它们活性的变化似乎与疾病症状的有无更密切相关。
