Moen T, Nousiainen H, Bratlie A, Solheim B G, Thorsby E
Hum Immunol. 1981 Jul;2(4):287-94. doi: 10.1016/0198-8859(81)90030-6.
In vitro priming experiments were performed with lymphocytes from members of two different families carrying Dw-,DR2 or Dw2,DR2 haplotypes. It was demonstrated that lymphocytes could be primed to allogeneic HLA-D determinants without detectable priming to the associated HLA-DR determinant, even when the priming cell was also HLA-DR incompatible to the responding cell. It was further shown that the unknown HLA-D determinants of the two families (e.g., Dw-) were different, one of them showing cross-reactivity to Dw2. Priming to MT1 determinants or to Lewis antigens could not be detected.
对携带Dw -、DR2或Dw2、DR2单倍型的两个不同家族成员的淋巴细胞进行了体外致敏实验。结果表明，淋巴细胞可被致敏至同种异体HLA - D决定簇，而对相关的HLA - DR决定簇无明显致敏，即使致敏细胞与应答细胞在HLA - DR上也不相容。进一步表明，这两个家族未知的HLA - D决定簇（如Dw -）不同，其中一个与Dw2有交叉反应性。未检测到对MT1决定簇或Lewis抗原的致敏。
