Proctor S J, Dickinson A M, Fail B, Walker W, Serisier S
J Clin Pathol. 1981 Aug;34(8):892-5. doi: 10.1136/jcp.34.8.892.
The measurement of terminal deoxynucleotidyl transferase (TDT) activity in leukaemic blasts of 26 cases of acute lymphoblastic leukaemia (ALL) (13 children less than 14 years, 13 adults greater than 14 years) demonstrated significantly greater activities of the enzyme on a proportion of the adults. The predominant cytological sub-type in the adult patients was L2 (FAB classification) whereas L1 cytological sub-type dominated in the childhood group. There was no relation between TDT values and FAB sub-type but the highest activities in the childhood group were seen in patients assessed at the time of relapse. We conclude that continued use of quantitative TDT estimations may provide useful information in further characterising the currently recognised cytological and immunological sub-types in ALL.
对26例急性淋巴细胞白血病(ALL)患者(13例年龄小于14岁的儿童,13例年龄大于14岁的成人)白血病原始细胞中的末端脱氧核苷酸转移酶(TDT)活性进行测量,结果显示部分成人患者的该酶活性明显更高。成年患者中主要的细胞学亚型为L2(FAB分类),而儿童组中L1细胞学亚型占主导。TDT值与FAB亚型之间没有关系,但儿童组中最高活性出现在复发时评估的患者中。我们得出结论,持续使用定量TDT估计可能会为进一步表征目前公认的ALL细胞学和免疫学分型提供有用信息。