Cohen T, Simhai B, Steinberg A G, Levene C
Am J Med Genet. 1981;8(2):181-90. doi: 10.1002/ajmg.1320080209.
Iranian Jews represent a very ancient Jewish community with a high frequency of inbreeding. A sample of Iranian Jews, mainly unrelated students, was tested for genetic markers of red blood cells and serum. The frequency of glucose-6-phosphate dehydrogenase deficiency was not uniform among Jews who had lived in different areas of Iran; it was lower among those from central Iran (6.7%) than in those from southern and western Iran (16.7% and 20.6%, respectively). The frequencies of B, CDe, cDE, S, and K alleles were among the highest recorded in Jewish ethnic groups. Iranian Jews were similar to Iraqi Jews with respect to the frequencies of the blood markers B, CDe, cde, cDe, ACP, PGM1, ADA, and Hp; however, the B and CDe markers occur with similar frequencies among indigenous Iranians. The presence of the cDe allele and the Gm1,5,13,14,17 haplotype in low frequencies indicates black admixture. Mongoloid admixture is indicated by the polymorphism of the Gm1,13,15,16,17 haplotype. The very rare phenotype Gm(3,5,13,14,17) was observed in 4.8% of 167 individuals tested. This phenotype has not been previously observed among Jews.
伊朗犹太人代表着一个非常古老的犹太社区，近亲繁殖的频率很高。对一组主要由无亲缘关系的学生组成的伊朗犹太人样本进行了红细胞和血清遗传标记检测。葡萄糖-6-磷酸脱氢酶缺乏症的频率在生活在伊朗不同地区的犹太人中并不一致；伊朗中部地区的犹太人中该频率较低（6.7%），低于伊朗南部和西部的犹太人（分别为16.7%和20.6%）。B、CDe、cDE、S和K等位基因的频率在犹太族群中是有记录以来最高的之一。在血液标记B、CDe、cde、cDe、ACP、PGM1、ADA和Hp的频率方面，伊朗犹太人与伊拉克犹太人相似；然而，B和CDe标记在伊朗本土人中出现的频率相似。低频出现的cDe等位基因和Gm1,5,13,14,17单倍型表明有黑人血统混合。Gm1,13,15,16,17单倍型的多态性表明有蒙古人种血统混合。在167名接受检测的个体中，有4.8%观察到了非常罕见的Gm(3,5,13,14,17)表型。这种表型此前在犹太人中未曾观察到。
