Javaid J I, Fischman M W, Schuster C R, Dekirmenjian H, Davis J M
Science. 1978 Oct 13;202(4364):227-8. doi: 10.1126/science.694530.
Volunteer subjects with previous histories of cocaine use were administered cocaine hydrochloride intravenously or intranasally. There was a positive relationship between peak plasma concentration, physiological and subjective responses, and dose administered. The rate of cocaine disappearance after intravenous administration paralleled the drop in physiological and subjective drug effects. After intranasal administration, blood levels remained elevated for a considerably longer period.
有可卡因使用史的志愿者受试者通过静脉注射或鼻内给药的方式被给予盐酸可卡因。血浆峰值浓度、生理反应和主观反应与给药剂量之间存在正相关关系。静脉注射后可卡因消失的速率与生理和主观药物效应的下降平行。鼻内给药后，血液水平在相当长的一段时间内保持升高。
