Balemans M G, Pévet P, van Benthem J, Haldar-Misra C, Smith I, Hendriks H
J Neural Transm. 1983;56(1):53-72. doi: 10.1007/BF01243374.
In the pineal, the Harderian gland and the retina of the golden hamster the day/night capacity for the synthesis of different methoxyindoles is investigated under natural conditions for one 24-hour period in the months of December, March and June. The amounts of the methoxyindoles and the diurnal rhythms in the synthesis are different in the various months during which the tests were performed. There is a striking increase in the synthesis of melatonin and methoxytryptophol in all three organs in June as compared with December. Equally striking is the high synthesis of methoxytryptamine in the pineal in June, whereas this compound was not formed in the Harderian gland and the retina in this month. Methoxytryptophan synthesis was not observed in June in any of the three organs. Methoxyindoleacetic acid rhythmicity shows a pattern more or less identical to that of melatonin and methoxytryptophol. A high synthesis exists at the end of the June day, but greater fluctuations during the days of the two other months. Acetylmethoxytryptophol is synthesized in the pineal during the night in March, but in the late afternoon in June. The largest quantity of this compound is found in the Harderian gland in December, in the pineal in March and in the retina in June. The largest amounts of melatonin and methoxytryptophol are synthesized when gonadal weight is largest. The possible correlation between the amounts synthesized, the rhythmicities in synthesis and the reproductive system is discussed.
在金仓鼠的松果体、哈德氏腺和视网膜中，于12月、3月和6月的自然条件下，对不同甲氧基吲哚在一个24小时周期内的昼夜合成能力进行了研究。在进行测试的不同月份中，甲氧基吲哚的含量以及合成中的昼夜节律各不相同。与12月相比，6月时所有这三个器官中褪黑素和甲氧基色醇的合成均显著增加。同样显著的是，6月时松果体中甲氧基色胺的合成量很高，而该化合物在当月的哈德氏腺和视网膜中并未形成。6月时在这三个器官中的任何一个中均未观察到甲氧基色氨酸的合成。甲氧基吲哚乙酸的节律呈现出与褪黑素和甲氧基色醇或多或少相同的模式。6月底存在较高的合成量，但在其他两个月的白天波动更大。3月时乙酰甲氧基色醇在松果体中于夜间合成，但6月时在傍晚合成。该化合物的最大量在12月的哈德氏腺中、3月的松果体中以及6月的视网膜中被发现。当性腺重量最大时，褪黑素和甲氧基色醇的合成量最大。文中讨论了合成量、合成节律与生殖系统之间可能存在的相关性。
