Al-Sabaawy Osama M
Department of Biochemistry, Nineveh College of Medicine, Mosul University, Mosul, Iraq.
Oman Med J. 2012 Jul;27(4):300-3. doi: 10.5001/omj.2012.74.
To evaluate the correlations of the serum concentrations of copper, zinc, and manganese with lipid profile parameters of adult men in Mosul City, Iraq.
The study included 51 apparently healthy adult men as a control group aged 34-62 years (group 1), and 31 hyperlipidemic patients aged 37-60 years (group 2). Trace elements copper, zinc and manganese were determined using atomic absorption spectrometry. Concentrations of total cholesterol, triglyceride and high density lipoprotein cholesterol were determined using enzymatic method. Indirect serum concentration of low-density lipoprotein cholesterol were calculated via the Friedewald formula. Data were evaluated as mean and standard deviation by analysis of variance (ANOVA) and t-test.
The results indicated that there is a significant lower level of serum zinc in hyperlipidemic patients compared with the control group, while copper and manganese showed no significant differences between the two groups. A significant negative correlation was found between serum zinc and total cholesterol, low-density lipoprotein cholesterol, triglyceride and low/high-density lipoprotein cholesterol ratio; while a significant positive correlation was found between serum zinc and high density lipoprotein cholesterol. In addition, a significant positive correlation between copper and triglyceride existed in the patient group, while the control group showed no such correlation.
Hyperlipidemia may possibly be related to a decrease in the level of serum zinc in hyperlipidemic adult men. The data also supports the concept that zinc supplementation might be useful in improving metabolic complications in subjects with hyperlipidemia.
评估伊拉克摩苏尔市成年男性血清铜、锌和锰浓度与血脂谱参数之间的相关性。
该研究纳入了51名年龄在34 - 62岁的明显健康成年男性作为对照组（第1组），以及31名年龄在37 - 60岁的高脂血症患者（第2组）。使用原子吸收光谱法测定微量元素铜、锌和锰。采用酶法测定总胆固醇、甘油三酯和高密度脂蛋白胆固醇的浓度。通过Friedewald公式计算低密度脂蛋白胆固醇的间接血清浓度。采用方差分析（ANOVA）和t检验将数据评估为均值和标准差。
结果表明，与对照组相比，高脂血症患者的血清锌水平显著降低，而两组之间铜和锰无显著差异。血清锌与总胆固醇、低密度脂蛋白胆固醇、甘油三酯以及低/高密度脂蛋白胆固醇比值之间存在显著负相关；而血清锌与高密度脂蛋白胆固醇之间存在显著正相关。此外，患者组中铜与甘油三酯之间存在显著正相关，而对照组未显示出这种相关性。
高脂血症可能与高脂血症成年男性血清锌水平降低有关。数据还支持补充锌可能有助于改善高脂血症患者代谢并发症的观点。
