表面修饰对磷脂囊泡聚集的影响。
Effect of surface modification on aggregation of phospholipid vesicles.
作者信息
Wu P S, Tin G W, Baldeschwieler J D, Shen T Y, Ponpipom M M
出版信息
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6211-5. doi: 10.1073/pnas.78.10.6211.
Abstract
Phospholipid vesicles have been extensively investigated because of their usefulness as models for biological membranes and their potential application as carriers for drug delivery. However, preparations of small sonicated vesicles tend to aggregate and fuse (on storage at room temperature and at 4 degrees C), resulting in significant changes in turbidity, rate of uptake by macrophage, and proton NMR linewidths. By modification of the surface of phospholipid vesicles with charged groups such as beta-aminogalactose that extend significantly from the vesicle surface, it is possible to obtain preparations that are stable for greater than 7 days.
摘要
磷脂囊泡因其作为生物膜模型的实用性以及作为药物递送载体的潜在应用而受到广泛研究。然而，小的超声处理囊泡制剂往往会聚集和融合（在室温及4摄氏度储存时），导致浊度、巨噬细胞摄取率和质子核磁共振线宽发生显著变化。通过用诸如β-氨基半乳糖等从囊泡表面显著延伸的带电基团修饰磷脂囊泡的表面，可以获得稳定超过7天的制剂。
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