Moran J, Addy M, Wade W G, Maynard J H, Roberts S E, Aström M, Movert R
Department of Periodontology, University of Wales College of Medicine, Cardiff, UK.
J Clin Periodontol. 1992 Nov;19(10):749-53. doi: 10.1111/j.1600-051x.1992.tb02165.x.
Delmopinol has been considered as a potential agent for the chemical control of plaque. The aims of these studies were to measure the effects of a 0.2% delmopinol hydrochloride mouthrinse on (1) plaque reformation and (2) salivary bacterial counts. Comparisons were made with a 0.2% chlorhexidine rinse and a placebo rinse. A group of 12 male volunteers took part in the plaque study which was of a double blind, randomised, 3 cell, cross-over design. From a zero plaque baseline subjects rinsed, 2x a day, under supervision, for 1 min with 10-ml volumes of the allocated rinse. After 4 days, during which no other form of oral hygiene was performed, plaque was scored by area and index. Plaque results were significantly lower with chlorhexidine and delmopinol compared with control, and with chlorhexidine compared to delmopinol. Side-effects with delmopinol were transient tingling and numbness of the tongue in some subjects. A 2nd group of 12 male volunteers received single, 1-min rinses of the 3 formulations. Salivary bacterial counts were determined immediately before and up to 420 min after rinsing. Compared to the control rinse, chlorhexidine significantly reduced bacterial counts of 420 min. Delmopinol produced a small reduction in bacterial counts which was only significantly different from control at one time point. Delmopinol deserves further evaluation as a chemical plaque inhibitor, particularly when used as an adjunct to normal toothcleaning.
地莫匹醇被认为是一种控制牙菌斑的潜在药物。这些研究的目的是测量0.2%盐酸地莫匹醇漱口水对（1）牙菌斑再形成和（2）唾液细菌计数的影响。与0.2%氯己定漱口水和安慰剂漱口水进行了比较。一组12名男性志愿者参与了牙菌斑研究，该研究采用双盲、随机、三单元、交叉设计。从牙菌斑零基线开始，受试者在监督下每天用10毫升分配的漱口水漱口两次，每次1分钟。4天后，在此期间不进行其他形式的口腔卫生护理，通过面积和指数对牙菌斑进行评分。与对照组相比，氯己定和地莫匹醇的牙菌斑结果显著更低，与地莫匹醇相比，氯己定的结果也更低。地莫匹醇的副作用是一些受试者出现短暂的舌头刺痛和麻木。第二组12名男性志愿者接受了三种制剂的单次1分钟漱口。在漱口前和漱口后长达420分钟测定唾液细菌计数。与对照漱口水相比，氯己定在420分钟时显著降低了细菌计数。地莫匹醇使细菌计数略有降低，仅在一个时间点与对照组有显著差异。地莫匹醇作为一种化学性牙菌斑抑制剂值得进一步评估，特别是当用作常规牙齿清洁的辅助手段时。
