Saper C B, Jarowski C I
Neurology. 1982 Jan;32(1):77-80. doi: 10.1212/wnl.32.1.77.
A 31-year-old woman with acute myelomonocytic leukemia presented with meningeal signs and a cerebellar mass attributed to leukemic infiltration. The mass disappeared with radiation therapy and intraventricular chemotherapy, but the patient subsequently suffered several spinal nerve root recurrences, disseminated herpes zoster, and progressive multifocal leukoencephalopathy. At autopsy, there was no trace of the meningeal leukemia or cerebellar infiltrate. This case illustrates several of the neurologic complications of acute nonlymphocytic leukemia, and raises the question whether patients with the myelomonocytic form of this disease might benefit from prophylactic central nervous system treatment.
一名31岁的急性粒单核细胞白血病女性患者出现脑膜刺激征及小脑肿块，考虑为白血病浸润所致。经放射治疗和脑室内化疗后肿块消失，但患者随后出现多次脊神经根复发、播散性带状疱疹及进行性多灶性白质脑病。尸检时，未发现脑膜白血病或小脑浸润的痕迹。该病例说明了急性非淋巴细胞白血病的几种神经系统并发症，并提出了患有这种疾病的粒单核细胞型患者是否可能从预防性中枢神经系统治疗中获益的问题。
