Emeriau J P, Deguilhem M, Borde C, Raynal F, Manciet G, Lorient M F, Boisseau M R, Galley P
Scand J Clin Lab Invest Suppl. 1981;156:217-20. doi: 10.3109/00365518109097466.
800 mg of pentoxifylline 400 was administered daily to two groups of elderly patients (average age 80 years) with the aim of increasing cerebral efficiency. Fifty patients (Group I) were treated for 30 days and of these, 25 patients (Group II) were treated for a further, 60 days. The programme included a battery of psychometric tests (Rey's R.P.M. Recit of Barbizet, coupled image tests, immediate memory test) two geriatric scales (Geriatric Rating Scale and Nosie 30) and study of the deformability of red cells. Results at the 30th and 90th day were compared with pre-experimental results: corrected filterability was increased (Group I and II, P less than 0.05), memory tests showed significant improvement (Group I and II, P less than 0.005), geriatric rating scale showed no modification. There was no correlation between changes in corrected filterability and improvement in psychometric tests.
为提高大脑功能，每天给两组老年患者（平均年龄80岁）服用800毫克己酮可可碱，其中400毫克为实际用量。一组50名患者（第一组）接受了30天的治疗，其中25名患者（第二组）又额外接受了60天的治疗。该项目包括一系列心理测试（雷氏修订渐进矩阵测验、巴比泽特复述测验、配对图像测试、即时记忆测试）、两个老年量表（老年评定量表和诺西30量表）以及红细胞变形性研究。将第30天和第90天的结果与实验前的结果进行比较：校正滤过率增加（第一组和第二组，P<0.05），记忆测试显示有显著改善（第一组和第二组，P<0.005），老年评定量表未显示有变化。校正滤过率的变化与心理测试的改善之间没有相关性。
