Khan M A, Kushner I, Braun W E, Zachary A A, Steinberg A G
Tissue Antigens. 1978 May;11(5):434-8. doi: 10.1111/j.1399-0039.1978.tb01280.x.
The observed frequency of apparent homozygotes for HLA--B27 (15.5%) was significantly greater than the estimated expected frequency (4.2%) among 58 B27-positive Caucasian patients with ankylosing spondylitis (AS) (P less than 0.0005). Search of the literature uncovered four other studies in each of which the frequency of apparent homozygotes was shown by our analysis to be greater than expected. These analyses indicated that B27 homozygotes are more susceptible to developing AS than are B27 heterozygotes. Comparison of the clinical features of AS showed no differences between heterozygotes and apparent homozygotes except for a higher frequency of involvement of peripheral joints in the latter group.
在58名患有强直性脊柱炎（AS）的B27阳性白种人患者中，观察到的HLA - B27明显纯合子频率（15.5%）显著高于估计的预期频率（4.2%）（P<0.0005）。文献检索发现另外四项研究，经我们分析，每项研究中明显纯合子的频率均高于预期。这些分析表明，B27纯合子比B27杂合子更易患AS。AS临床特征的比较显示，杂合子和明显纯合子之间没有差异，只是后一组外周关节受累的频率较高。
