Bray M A, Powell R G, Lydyard P M
Int J Immunopharmacol. 1981;3(4):377-81. doi: 10.1016/0192-0561(81)90033-3.
Prostaglandins (PGs) have been widely implicated as modulators of immuno-inflammatory reactions. The cellular source of such immunoregulatory PGs has generally been thought to be the macrophage/monocyte, however several workers have suggested that adherent T-lymphocytes may be involved. We have attempted to resolve this question and have assayed PGE2 and thromboxane B2 release by purified sub-populations of human blood lymphocytes. Separated lymphocyte populations produce little PGEs when compared to monocytes and we concluded that the levels of PGs generated could be explained by monocyte contamination. In conclusion, we feel that the monocyte/macrophage acts as the source of immunoregulatory prostaglandins.
前列腺素（PGs）作为免疫炎症反应的调节剂已被广泛涉及。这类免疫调节性PGs的细胞来源通常被认为是巨噬细胞/单核细胞，然而一些研究人员认为黏附的T淋巴细胞可能也参与其中。我们试图解决这个问题，并检测了人血淋巴细胞纯化亚群释放的前列腺素E2（PGE2）和血栓素B2（TXB2）。与单核细胞相比，分离出的淋巴细胞群体产生的PGEs很少，我们得出结论，所产生的PGs水平可以用单核细胞污染来解释。总之，我们认为单核细胞/巨噬细胞是免疫调节性前列腺素的来源。
