Smevik B, Klepp O
Cancer. 1982 Apr 15;49(8):1734-7. doi: 10.1002/1097-0142(19820415)49:8<1734::aid-cncr2820490833>3.0.co;2-k.
Seven cases of unilateral, spontaneous pneumothorax were found in a retrospective study of 63 patients with osteogenic sarcoma who were admitted to The Norwegian Radium Hospital (NRH) in the period 1970--1977. The relative risk of pneumothorax developing doubled, from 7--14%, after the introduction of chemotherapy for this disease at NRH. This difference was not statistically significant. Pneumothorax developed in two of 18 patients (11%) with lung metastases who never received chemotherapy. Pneumothorax occurred in four of 19 patients (21%) treated with chemotherapy for manifest lung metastases, and in one of eight patients (13%) who received adjuvant chemotherapy, but in whom lung metastases developed later. Pneumothorax did not develop in 79 patients treated with chemotherapy for disseminated testicular cancer, despite the fact that 82% of these patients had manifest lung metastases.
在对1970年至1977年间入住挪威镭医院（NRH）的63例骨肉瘤患者进行的回顾性研究中，发现了7例单侧自发性气胸病例。在NRH引入针对该疾病的化疗后，气胸发生的相对风险增加了一倍，从7%升至14%。但这种差异无统计学意义。18例从未接受化疗的肺转移患者中有2例（11%）发生了气胸。19例因明显肺转移接受化疗的患者中有4例（21%）发生了气胸，8例接受辅助化疗但后来出现肺转移的患者中有1例（13%）发生了气胸。79例因播散性睾丸癌接受化疗的患者未发生气胸，尽管其中82%的患者有明显的肺转移。
