口服维甲酸类药物的一般临床毒理学

General clinical toxicology of oral retinoids.

作者信息

Windhorst D B, Nigra T

出版信息

J Am Acad Dermatol. 1982 Apr;6(4 Pt 2 Suppl):675-82. doi: 10.1016/s0190-9622(82)70056-8.

Abstract

Four retinoids - retinol (vitamin A), tretinoin (retinoic acid), etretinate (the ethyl ester of trimethoxymethylphenyl retinoic acid), and isotretinoin (13-cis-retinoic acid, Accutane) - have been administered orally in humans for therapeutic purposes. A review of the available information on the clinical toxic effects of these substances indicated that, while they express similar spectra of toxicity, they also differ in the extent to which they affect various body systems. This suggests that differential efficacy of the retinoids may be related, in part, to the cutaneous sites of maximum activity.

摘要

四种维甲酸——视黄醇（维生素A）、维甲酸（视黄酸）、阿维A酯（三甲氧基甲基苯基维甲酸乙酯）和异维A酸（13-顺式视黄酸，异维甲酸）——已被口服用于人类的治疗目的。对这些物质临床毒性作用的现有信息进行的综述表明，虽然它们表现出相似的毒性谱，但它们对各个身体系统的影响程度也有所不同。这表明维甲酸的不同疗效可能部分与最大活性的皮肤部位有关。