Carr M E, Hadler N M
Arthritis Rheum. 1980 Dec;23(12):1371-5. doi: 10.1002/art.1780231207.
The permeability of hyaluronic acid solutions was measured in a chamber closed at each end of semi-permeable membranes. Permeability was strongly concentration dependent below 1.0 gm% hyaluronic acid. Small changes in the ionic environment of 1.0 gm% hyaluronic acid solutions also altered permeability. The permeability of such solutions decreased by a factor of 4.7 in the presence of as little as 5 mM calcium ion and showed optimum permeability at pH 7.0. The pH optimum was not noted in hyaluronic acid preparations known to contain only small amounts of protein.
在两端封闭有半透膜的腔室内测量透明质酸溶液的渗透率。在透明质酸浓度低于1.0 gm%时，渗透率强烈依赖于浓度。1.0 gm%透明质酸溶液离子环境的微小变化也会改变渗透率。在仅存在低至5 mM钙离子的情况下，此类溶液的渗透率降低了4.7倍，并且在pH 7.0时显示出最佳渗透率。在已知仅含有少量蛋白质的透明质酸制剂中未观察到最佳pH值。
