Stewart J, Glass E J, Weir D M
Nature. 1982 Aug 26;298(5877):852-4. doi: 10.1038/298852a0.
Cell surface interactions involving carbohydrate may be important in immune recognition. Previous work from this laboratory has demonstrated the presence of 'lectin-like' receptors on mouse peritoneal macrophages that bind bacteria by means of their cell wall sugars. Others have shown that Ia molecules can bind antigen at specific sites which may be involved in presenting antigen to the immune system and recent work has shown that these molecules can carry carbohydrate determinants. It has also been found that human Ia molecules can bind to carbohydrates. As cell surface carbohydrate recognition mechanisms have been implicated in other immune interactions sugar-specific receptors may have a function in self--non-self recognition. We show here that the binding of the bacterium Staphylococcus albus to mouse peritoneal macrophages was inhibited by various conventional and monoclonal antibodies to Ia antigens suggesting that an I-region gene product may be associated with the binding of unopsonized bacteria.
涉及碳水化合物的细胞表面相互作用在免疫识别中可能很重要。本实验室先前的研究表明，小鼠腹腔巨噬细胞上存在“凝集素样”受体，该受体通过细菌细胞壁糖类结合细菌。其他人已经表明，Ia分子可以在特定部位结合抗原，这些部位可能参与将抗原呈递给免疫系统，最近的研究表明这些分子可以携带碳水化合物决定簇。还发现人类Ia分子可以与碳水化合物结合。由于细胞表面碳水化合物识别机制与其他免疫相互作用有关，糖特异性受体可能在自身-非自身识别中发挥作用。我们在此表明，各种针对Ia抗原的传统抗体和单克隆抗体可抑制白色葡萄球菌与小鼠腹腔巨噬细胞的结合，这表明I区基因产物可能与未调理细菌的结合有关。
