Glass E J, Stewart J, Matthews D M, Collier A, Clarke B F, Weir D M
Diabetologia. 1987 Apr;30(4):228-31. doi: 10.1007/BF00270420.
In order to investigate whether the ability of peripheral blood monocytes to bind bacteria is impaired in diabetes, we studied carbohydrate-binding ("lectin-like") receptors and the receptor for the Fc portion of immunoglobulin on monocytes from 25 male Type 1 (insulin-dependent) diabetic patients and 10 age-matched healthy control subjects. Peripheral blood monocytes from the diabetic patients expressed lower levels of "lectin-like" receptors compared to the control subjects, whereas the expression of the receptor for the Fc portion of immunoglobulin was similar in both populations. There was no correlation between the degree of "lectin-like" binding activity and plasma glucose concentration or glycaemic control. Recognition of unopsonized bacteria by the "lectin-like" receptor is impaired in Type 1 diabetes; this may affect the efficient elimination of potential pathogens.
为了研究糖尿病患者外周血单核细胞结合细菌的能力是否受损，我们对25名1型（胰岛素依赖型）男性糖尿病患者和10名年龄匹配的健康对照者的单核细胞上的碳水化合物结合（“凝集素样”）受体以及免疫球蛋白Fc部分的受体进行了研究。与对照者相比，糖尿病患者外周血单核细胞表达的“凝集素样”受体水平较低，而免疫球蛋白Fc部分受体的表达在两组人群中相似。“凝集素样”结合活性程度与血浆葡萄糖浓度或血糖控制之间无相关性。1型糖尿病患者中“凝集素样”受体对未调理细菌的识别受损；这可能会影响潜在病原体的有效清除。
