真核生物核糖体能够识别胰岛素原起始密码子，而不论其相对于mRNA 5'端的位置如何。
Eukaryotic ribosomes can recognize preproinsulin initiation codons irrespective of their position relative to the 5' end of mRNA.
作者信息
Lomedico P T, McAndrew S J
出版信息
Nature. 1982 Sep 16;299(5880):221-6. doi: 10.1038/299221a0.
DOI:10.1038/299221a0
PMID:6955600
Abstract
The functional assay of a eukaryotic mRNA, into which additional AUG codons have been introduced by in vitro mutagenesis, shows that a translational initiation site need not necessarily be the nearest AUG codon to the 5' end of a mRNA. Hence, the sequence surrounding the AUG, and not simply its position relative to the 5' end of mRNA, appears to be important in determining initiation efficiency.
摘要
对通过体外诱变引入了额外AUG密码子的真核生物mRNA进行功能分析，结果表明，翻译起始位点不一定是mRNA 5'端最靠近的AUG密码子。因此，AUG周围的序列，而不仅仅是其相对于mRNA 5'端的位置，在决定起始效率方面似乎很重要。
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