从cDNA序列推导的猴轮状病毒SA11中和抗原的一级结构。
Primary structure of the neutralization antigen of simian rotavirus SA11 as deduced from cDNA sequence.
作者信息
Arias C F, López S, Bell J R, Strauss J H
出版信息
J Virol. 1984 May;50(2):657-61. doi: 10.1128/JVI.50.2.657-661.1984.
Abstract
DNA sequences complementary to the double-stranded RNA coding for the neutralization antigen (glycoprotein VP7) of simian rotavirus SA11 have been cloned. The VP7 gene consists of 1,062 nucleotides, containing an uninterrupted coding sequence of 978 nucleotides which specifies a glycoprotein of 326 amino acids. The significance of a second possible initiation site 30 nucleotides downstream from the first is discussed. Partial amino acid sequence of this glycoprotein showed unequivocally that the cloned segment (segment 9) codes for glycoprotein VP7 of SA11. The resulting amino acid sequence contained only one carbohydrate acceptor site. Possible sites of membrane interaction and antigenic determinants are discussed based on the analysis of the hydrophobicity and hydrophilicity profiles of VP7.
摘要
与编码猿猴轮状病毒SA11中和抗原（糖蛋白VP7）的双链RNA互补的DNA序列已被克隆。VP7基因由1062个核苷酸组成，包含一个978个核苷酸的不间断编码序列，该序列编码一个由326个氨基酸组成的糖蛋白。讨论了第一个起始位点下游30个核苷酸处第二个可能起始位点的意义。该糖蛋白的部分氨基酸序列明确表明，克隆片段（片段9）编码SA11的糖蛋白VP7。所得氨基酸序列仅包含一个碳水化合物受体位点。基于对VP7疏水性和亲水性图谱的分析，讨论了膜相互作用和抗原决定簇的可能位点。
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