腹膜巨噬细胞和贴壁脾细胞合成胸腺素β4 。
Synthesis of thymosin beta 4 by peritoneal macrophages and adherent spleen cells.
作者信息
Xu G J, Hannappel E, Morgan J, Hempstead J, Horecker B L
出版信息
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4006-9. doi: 10.1073/pnas.79.13.4006.
Abstract
Thymosin beta 4, previously identified as a component of thymosin fraction 5 isolated from calf thymus, is synthesized by peritoneal macrophages derived from rats or mice, including cells from nu/nu mice. Identification of thymosin beta 4 containing [35S]methionine was based on its retention time in reverse-phase HPLC and the recovery of radioactivity in peptides generated by mild acid hydrolysis or by digestion with trypsin. Thymosin beta 4 is also synthesized by rat and mouse spleen cells, and evidence is presented for its release from these cells.
摘要
胸腺素β4，先前被鉴定为从小牛胸腺中分离出的胸腺素组分5的一种成分，由源自大鼠或小鼠（包括裸鼠细胞）的腹腔巨噬细胞合成。含有[35S]甲硫氨酸的胸腺素β4的鉴定基于其在反相高效液相色谱中的保留时间以及由温和酸水解或胰蛋白酶消化产生的肽中的放射性回收率。胸腺素β4也由大鼠和小鼠脾细胞合成，并且有证据表明它从这些细胞中释放出来。
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本文引用的文献
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Proc Natl Acad Sci U S A. 1982 Apr;79(7):2172-5. doi: 10.1073/pnas.79.7.2172.
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