Goebel K M, von Manteuffel G, Zehner J, Gerdes H
Wien Klin Wochenschr. 1978 Oct 13;90(19):690-5.
The effect of 6-methylprednisolone (GCC) was studied on erythropoietin (ESF) levels and on the metabolic functions of erythrocytes (RBC). GCC (U mg/kg/day for 15 days) was administered to 6 patients with the haemolytic-uraemic syndrome (group B) and to 6 patients with non-spherocytic haemolytic anaemia due to hereditary pyruvate kinase enzyme deficiency (group C). 6 healthy persons served as control (group A). The metabolic functions of RBC were investigated by assaying HMPS activity, GSH/GSSG and lactate/pyruvate ratios, relevant glycolytic intermediates, 2,3-DPG, ATP, and key enzymes. A significant increase in ESF was observed in group B patients after GCC therapy, correlating with an improvement in the haemolytic state, and consequent rectification of the secondary disturbances of RBC metabolism. Group C patients already had raised ESF levels before GCC therapy; no further increase occured in response to treatment and no other clinical or haematological change was recorded. Hence, no harmonal influence of GCC on the disturbed RBC metabolic process was detectable in the cases.
研究了6-甲基强的松龙（GCC）对促红细胞生成素（ESF）水平及红细胞（RBC）代谢功能的影响。对6例溶血尿毒综合征患者（B组）和6例因遗传性丙酮酸激酶酶缺乏导致的非球形细胞溶血性贫血患者（C组）给予GCC（U毫克/千克/天，共15天）。6名健康人作为对照（A组）。通过检测己糖单磷酸支路（HMPS）活性、谷胱甘肽/氧化型谷胱甘肽（GSH/GSSG）和乳酸/丙酮酸比值、相关糖酵解中间产物、2,3-二磷酸甘油酸（2,3-DPG）、三磷酸腺苷（ATP）及关键酶来研究RBC的代谢功能。GCC治疗后，B组患者的ESF显著升高，这与溶血状态的改善以及RBC代谢继发紊乱的纠正相关。C组患者在GCC治疗前ESF水平就已升高；治疗后未进一步升高，也未记录到其他临床或血液学变化。因此，在这些病例中未检测到GCC对紊乱的RBC代谢过程有激素影响。
