Erckenbrecht E, Berges W, Sonnenberg A, Erckenbrecht J, Wienbeck M
Scand J Gastroenterol Suppl. 1982;72:185-90.
The effect of pirenzepine on esophageal motility was studied in ten healthy volunteers by manometry. Pirenzepine reduces lower esophageal sphincter pressure (LESP), amplitude, and duration of esophageal contractions, but it increases velocity of propagation of esophageal contractions. On the other hand, it is known that pirenzepine inhibits gastric acid secretion. Therefore, the reduction of contractile force in the esophagus caused by pirenzepine does not necessarily mean an increased risk of peptic gastroesophageal reflux.
通过测压法在10名健康志愿者中研究了哌仑西平对食管动力的影响。哌仑西平可降低食管下括约肌压力（LESP）、食管收缩的幅度和持续时间，但会增加食管收缩的传播速度。另一方面，已知哌仑西平可抑制胃酸分泌。因此，哌仑西平引起的食管收缩力降低并不一定意味着消化性胃食管反流风险增加。
