Brunner H
Scand J Gastroenterol Suppl. 1982;72:207-9.
In a randomized, controlled multicenter-study 126 patients with endoscopically proven duodenal ulcer were treated with 100 mg Pirenzepine daily and 128 patients with 1000 mg Cimetidine daily. Endoscopic evaluation was done by an independent endoscopist after four weeks. At this time 64.3% of the Pirenzepine-treated patients and 73.4% of the patients on Cimetidine had the ulcer healed. The chi-square value of 2.48 indicates that the difference was not statistically significant, that Pirenzepine is equally or at least not essentially less effective than Cimetidine in the treatment of duodenal ulcer. Pain relief was good in both groups with a trend in favour of Cimetidine. Side effects were seldom, mild and reversible.
在一项随机对照多中心研究中，126例经内镜证实为十二指肠溃疡的患者每日服用100毫克哌仑西平，128例患者每日服用1000毫克西咪替丁。四周后由一名独立的内镜医师进行内镜评估。此时，服用哌仑西平的患者中有64.3%溃疡愈合，服用西咪替丁的患者中有73.4%溃疡愈合。卡方值为2.48，表明差异无统计学意义，即哌仑西平在治疗十二指肠溃疡方面与西咪替丁同样有效或至少不比其差。两组的疼痛缓解情况均良好，且有西咪替丁更具优势的趋势。副作用很少，症状轻微且可逆转。
